Superior Survival Outcomes of a Polyethylene Glycol-20k Based Resuscitation Solution
Annals of Surgery - Superior early and 24-hour outcomes were observed with PEG-20k LVR compared to WB and Hextend in a preclinical porcine model of lethal HS, despite decreased OCC from substantial volume-expansion
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Effects of Polyethylene Glycol‐20k on Coronary Perfusion Pressure and Postresuscitation Myocardial.
Journal of the American Heart Association - Aortic infusion of PEG‐20k during cardiopulmonary resuscitation increases coronary perfusion pressure to the same extent as epinephrine, improves postresuscitation myocardial and cerebral function, and increases duration of survival in a rat model of cardiac arrest.
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Low-volume resuscitation using polyethylene glycol-20k in a preclinical porcine model…
The Journal of Trauma and Acute Care Surgery - In a preclinical model of controlled hemorrhagic shock, PEG-20k-based LVR solution increased tolerance to the shock state 16-fold compared to saline.
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Cell Impermeant-based Low-volume Resuscitation in Hemorrhagic Shock
Annals of Surgery - Ischemia-induced lethal cell swelling during hemorrhagic shock is a key mediator of resuscitation injury, which can be prevented by cell impermeants in low-volume resuscitation solutions.
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